MAPK8IP1 Polyclonal Antibody

• Background :

  This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8) . This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.

• Description :

  This is a MAPK8IP1 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms :

  MAPK8IP1, IB1, JIP-1, JIP1, PRKM8IP

• Gene ID :

  9479

• Swiss Prot :

  Q9UQF2

• Reactivity :

  Human, Mouse

• Immunogen :

  Recombinant fusion protein of human MAPK8IP1

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Polyclonal Antibody

• Applications :

  WB

• Purification Method :

  Affinity purification

• Assay Type :

  Antibody

• Concentration :

  1mg/mL

• Dilution :

  WB 1:200-1:2000

• Buffer :

  PBS with 0.02% sodium azide,50% glycerol, pH7.3.

• Storage Conditions :

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  40kDa/60kDa/105kDa/110kDa

• Observed Molecular Weight :

  110kDa

• Host or Source :

  Rabbit

• Isotype :

  IgG