MAPK8IP1 Polyclonal Antibody

• Background:

  This gene encodes a regulator of the pancreatic beta-cell function. It is highly similar to JIP-1, a mouse protein known to be a regulator of c-Jun amino-terminal kinase (Mapk8) . This protein has been shown to prevent MAPK8 mediated activation of transcription factors, and to decrease IL-1 beta and MAP kinase kinase 1 (MEKK1) induced apoptosis in pancreatic beta cells. This protein also functions as a DNA-binding transactivator of the glucose transporter GLUT2. RE1-silencing transcription factor (REST) is reported to repress the expression of this gene in insulin-secreting beta cells. This gene is found to be mutated in a type 2 diabetes family, and thus is thought to be a susceptibility gene for type 2 diabetes.

• Description:

  This is a MAPK8IP1 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms:

  MAPK8IP1, IB1, JIP-1, JIP1, PRKM8IP

• Gene ID:

  9479

• Swiss Prot:

  Q9UQF2

• Reactivity:

  Human, Mouse

• Immunogen:

  Recombinant fusion protein of human MAPK8IP1

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Polyclonal Antibody

• Applications:

  WB

• Purification Method:

  Affinity purification

• Assay Type:

  Antibody

• Concentration:

  1mg/mL

• Dilution:

  WB 1:200-1:2000

• Buffer:

  PBS with 0.02% sodium azide,50% glycerol, pH7.3.

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  40kDa/60kDa/105kDa/110kDa

• Observed Molecular Weight:

  110kDa

• Host or Source:

  Rabbit

• Isotype:

  IgG