MAPKBP1 Polyclonal Antibody

• Background:

  This gene encodes a scaffold protein that regulates the JNK (c-Jun N-terminal kinase) and NOD2 (nucleotide-binding oligomerization domain-containing protein 2) signaling pathways. The encoded protein interacts with another related JNK pathway scaffold protein, WDR62, via a conserved dimerization domain, and enhances JNK signaling. This protein may play a role in bacterial immunity by binding to the NOD2 receptor and negatively regulating downstream antibacterial and pro-inflammatory signaling. Mutations in this gene that impair cellular localization of the encoded protein cause a form of nephronophthisis, an autosomal-recessive kidney disorder, in human patients.

• Description:

  This is a MAPKBP1 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms:

  MAPKBP1, JNKBP-1, JNKBP1, NPHP20

• Gene ID:

  23005

• Swiss Prot:

  O60336

• Reactivity:

  Human, Mouse

• Immunogen:

  A synthetic peptide of human MAPKBP1

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Polyclonal Antibody

• Applications:

  WB

• Purification Method:

  Affinity purification

• Assay Type:

  Antibody

• Concentration:

  1mg/mL

• Dilution:

  WB 1:500-1:2000

• Buffer:

  PBS with 0.02% sodium azide,50% glycerol, pH7.3.

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  14kDa/17kDa/26kDa

• Observed Molecular Weight:

  26kDa

• Host or Source:

  Rabbit

• Isotype:

  IgG