MAP3K8 Polyclonal Antibody

• Background:

  This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein.

• Description:

  This is a MAP3K8 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms:

  MAP3K8, AURA2, COT, EST, ESTF, MEKK8, TPL2, Tpl-2, c-COT

• Gene ID:

  1326

• Swiss Prot:

  P41279

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  A synthetic peptide of human MAP3K8

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Polyclonal Antibody

• Applications:

  WB

• Purification Method:

  Affinity purification

• Assay Type:

  Antibody

• Concentration:

  1mg/mL

• Dilution:

  WB 1:500-1:2000

• Buffer:

  PBS with 0.01% thiomersal,50% glycerol, pH7.3.

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  63kDa/75kDa/77kDa/79kDa

• Observed Molecular Weight:

  79KDa

• Host or Source:

  Rabbit

• Isotype:

  IgG