HLA-DOB Polyclonal Antibody

• Background:

  HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages) . The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.

• Description:

  This is a HLA-DOB Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms:

  HLA-DOB, DOB, HLA_DOB, major histocompatibility complex, class II, DO beta

• Gene ID:

  3112

• Swiss Prot:

  P13765

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein of human HLA-DOB

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Polyclonal Antibody

• Applications:

  WB

• Purification Method:

  Affinity purification

• Assay Type:

  Antibody

• Concentration:

  1mg/mL

• Dilution:

  WB 1:500-1:2000

• Buffer:

  PBS with 0.01% thiomersal,50% glycerol, pH7.3.

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  58kDa/60kDa

• Observed Molecular Weight:

  60kDa

• Host or Source:

  Rabbit

• Isotype:

  IgG