CD22 Polyclonal Antibody

• Background:

  CD22, also known as Siglec-2 (sialic acid binding Ig-like lectin 2) or BL-CAM (B-lymphocyte cell adhesion molecule), is a 130-140 kDa, B-cell restricted, type I transmembrane glycoprotein belonging to the immunoglobulin gene superfamily. The expression of CD22 is developmentally regulated. It is expressed at low levels in the cytoplasm of pro-B and pre-B cells and present on the cell surface only at mature stages of B-cell differentiation. Cell surface expression is lost during terminal differentiation into plasma cell and after B-cell activation. CD22 is an inhibitory receptor for B-cell receptor (BCR) signalling, preferentially binds to alpha-2,6-linked sialic acid and mediates B-cell B-cell interactions. It plays a crucial role in activation and differentiation of the B-cell.

• Description:

  This is a CD22 Polyclonal antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms:

  B cell receptor CD22 precursor, B lymphocyte cell adhesion molecule, BL CAM, CD 22, CD22 antigen, CD22 molecule, Lectin 2, Leu14, Lyb8, MGC130020, sialic acid binding Ig like lectin 2, SIGLEC 2, T cell surface antigen Leu 14

• Swiss Prot:

  P20273

• Reactivity:

  Human

• Immunogen:

  Recombinant Human CD22 protein expressed by E.coli

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Polyclonal antibody

• Applications:

  WB, IHC

• Purification Method:

  Affinity purification

• Assay Type:

  Antibody

• Concentration:

  1 mg/mL

• Dilution:

  WB 1:500-1:1000, IHC 1:200-1:400

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH 7.4

• Storage Conditions:

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  34 kDa

• Observed Molecular Weight:

  45 kDa

• Host or Source:

  Rabbit

• Isotype:

  IgG