CD22 Polyclonal Antibody

• Background :

  CD22, also known as Siglec-2 (sialic acid binding Ig-like lectin 2) or BL-CAM (B-lymphocyte cell adhesion molecule), is a 130-140 kDa, B-cell restricted, type I transmembrane glycoprotein belonging to the immunoglobulin gene superfamily. The expression of CD22 is developmentally regulated. It is expressed at low levels in the cytoplasm of pro-B and pre-B cells and present on the cell surface only at mature stages of B-cell differentiation. Cell surface expression is lost during terminal differentiation into plasma cell and after B-cell activation. CD22 is an inhibitory receptor for B-cell receptor (BCR) signalling, preferentially binds to alpha-2,6-linked sialic acid and mediates B-cell B-cell interactions. It plays a crucial role in activation and differentiation of the B-cell.

• Description :

  This is a CD22 Polyclonal antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms :

  B cell receptor CD22 precursor, B lymphocyte cell adhesion molecule, BL CAM, CD 22, CD22 antigen, CD22 molecule, Lectin 2, Leu14, Lyb8, MGC130020, sialic acid binding Ig like lectin 2, SIGLEC 2, T cell surface antigen Leu 14

• Swiss Prot :

  P20273

• Reactivity :

  Human

• Immunogen :

  Recombinant Human CD22 protein expressed by E.coli

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Polyclonal antibody

• Applications :

  WB, IHC

• Purification Method :

  Affinity purification

• Assay Type :

  Antibody

• Concentration :

  1 mg/mL

• Dilution :

  WB 1:500-1:1000, IHC 1:200-1:400

• Buffer :

  PBS with 0.02% sodium azide, 50% glycerol, pH 7.4

• Storage Conditions :

  Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  34 kDa

• Observed Molecular Weight :

  45 kDa

• Host or Source :

  Rabbit

• Isotype :

  IgG