CD22 Polyclonal Antibody

CAT: 0866-RD90674A-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0866-RD90674A-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
CD22, also known as Siglec-2 (sialic acid binding Ig-like lectin 2) or BL-CAM (B-lymphocyte cell adhesion molecule), is a 130-140 kDa, B-cell restricted, type I transmembrane glycoprotein belonging to the immunoglobulin gene superfamily. The expression of CD22 is developmentally regulated. It is expressed at low levels in the cytoplasm of pro-B and pre-B cells and present on the cell surface only at mature stages of B-cell differentiation. Cell surface expression is lost during terminal differentiation into plasma cell and after B-cell activation. CD22 is an inhibitory receptor for B-cell receptor (BCR) signalling, preferentially binds to alpha-2,6-linked sialic acid and mediates B-cell B-cell interactions. It plays a crucial role in activation and differentiation of the B-cell.
Description
This is a CD22 Polyclonal antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
B cell receptor CD22 precursor, B lymphocyte cell adhesion molecule, BL CAM, CD 22, CD22 antigen, CD22 molecule, Lectin 2, Leu14, Lyb8, MGC130020, sialic acid binding Ig like lectin 2, SIGLEC 2, T cell surface antigen Leu 14
Swiss Prot
P20273
Reactivity
Human
Immunogen
Recombinant Human CD22 protein expressed by E.coli
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal antibody
Applications
WB, IHC
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1 mg/mL
Dilution
WB 1:500-1:1000, IHC 1:200-1:400
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH 7.4
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
34 kDa
Observed Molecular Weight
45 kDa
Host or Source
Rabbit
Isotype
IgG

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