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CNOT1 Polyclonal Antibody

CAT: 0866-RD89721A-01Size: 60 μLDry Ice: NoHazardous: No
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CAT#:0866-RD89721A-01Size:60 μL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Scaffolding component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Its scaffolding function implies its interaction with the catalytic complex module and diverse RNA-binding proteins mediating the complex recruitment to selected mRNA 3'UTRs. Involved in degradation of AU-rich element (ARE-containing mRNAs probably via association with ZFP36. Mediates the recruitment of the CCR4-NOT complex to miRNA targets and to the RISC complex via association with TNRC6A, TNRC6B or TNRC6C. Acts as a transcriptional repressor. Represses the ligand-dependent transcriptional activation by nuclear receptors. Involved in the maintenance of embryonic stem (ES cell identity.
Description
This is a CNOT1 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
CNOT1, AD-005, CDC39, NOT1, NOT1H
Gene ID
23019
Swiss Prot
A5YKK6
Reactivity
Human, Mouse
Immunogen
Recombinant fusion protein of human CNOT1
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB, IF
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1mg/mL
Dilution
WB 1:200-1:2000, IF 1:50-1:200
Buffer
PBS with 0.01% thiomersal,50% glycerol, pH7.3.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
54kDa
Observed Molecular Weight
65kDa
Host or Source
Rabbit
Isotype
IgG

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