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(KD Validated) Smad4 Polyclonal Antibody

CAT: 0866-RD89408A-01Size: 60 μLDry Ice: NoHazardous: No
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CAT#:0866-RD89408A-01Size:60 μL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE) . The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome.
Description
This is a (KD Validated) Smad4 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
SMAD4, DPC4, JIP, MADH4, MYHRS, SMAD family member 4
Gene ID
4089
Swiss Prot
Q13485
Reactivity
Human, Mouse
Immunogen
Recombinant fusion protein of human Smad4
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1mg/mL
Dilution
WB 1:500-1:2000
Buffer
PBS with 0.05% proclin300,50% glycerol, pH7.3.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
57kDa/71kDa
Observed Molecular Weight
120KDa
Host or Source
Rabbit
Isotype
IgG

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