CSTB Polyclonal Antibody

CAT: 0866-RD89387A-01Size: 60 μLDry Ice: NoHazardous: No
CAT#:0866-RD89387A-01Size:60 μL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and kininogens. This gene encodes a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1) . One type of mutation responsible for EPM1 is the expansion in the promoter region of this gene of a CCCCGCCCCGCG repeat from 2-3 copies to 30-78 copies.
Description
This is a CSTB Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
CSTB, CPI-B, CST6, EPM1, EPM1A, PME, STFB, ULD, cystatin-B
Gene ID
1476
Swiss Prot
P04080
Reactivity
Human
Immunogen
Recombinant fusion protein of human CSTB
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB, IHC
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1mg/mL
Dilution
WB 1:500-1:2000, IHC 1:50-1:200
Buffer
PBS with 0.02% sodium azide,50% glycerol, pH7.3.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
65-72kDa/90-108kDa
Observed Molecular Weight
Refer to figures
Host or Source
Rabbit
Isotype
IgG

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