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TFEB Polyclonal Antibody

CAT: 0866-RD90326A-01Size: 60 μLDry Ice: NoHazardous: No
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CAT#:0866-RD90326A-01Size:60 μL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Transcription factor that acts as a master regulator of lysosomal biogenesis, autophagy, lysosomal exocytosis, lipid catabolism, energy metabolism and immune response. Specifically recognizes and binds E-box sequences (5'-CANNTG-3'; efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFEB phosphorylation by MTOR promotes its cytosolic retention and subsequent inactivation. Upon starvation or lysosomal stress, inhibition of MTOR induces TFEB dephosphorylation, resulting in nuclear localization and transcription factor activity.
Description
This is a TFEB Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
TFEB, ALPHATFEB, BHLHE35, TCFEB
Gene ID
7942
Swiss Prot
P34897
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein of human TFEB
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB, IHC, IF
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1mg/mL
Dilution
WB 1:500-1:2000, IHC 1:50-1:200, IF 1:50-1:200
Buffer
PBS with 0.01% thiomersal,50% glycerol, pH7.3.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
10kDa/29kDa/35kDa/42kDa/45kDa
Observed Molecular Weight
48KDa
Host or Source
Rabbit
Isotype
IgG

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