Anti-BoNT-A | Botulinum toxin A

Anti-BoNT-A | Botulinum toxin A

• Background: Botulinum toxinis a toxin produced by the anaerobic, gram-positive, bacterium of the genusClostridium(C. botulinum, C. butyricum, C. baratii and C. argentinense).These strains are widely distributed and can be found in soil and dust. Eight types of botulinum toxin are distinguished, named type A–H. Type A and B are capable of causing disease in humans (botulism) and have longest activity in vivo, and are also used commercially (BOTOX) and medically. Types C–G are less common; types E and F can cause disease in humans, while the other types cause disease in other animals. BotA is cleaved into two chains: heavy and light.Alternative name: Bontoxilysin-A
• CAS Number: 9007-83-4
• Host: Rabbit
• Reactivity: Botulinum toxin A heavy chain
• Not reactive in: No confirmed exceptions from predicted reactivity are currently known
• Immunogen: Recombinat C-terminal heavy chain of BoNT/A1, residues 876–1296, which was cloned into a pET28a His-tag vector (Novagen) and overexpressed inE.coli. UniProt:https://www.uniprot.org/uniprot/P10845
• Clonality: Polyclonal
• Applications: ELISA (ELISA)
• Dilution: To be determined by end user
• Purity: Total IgG. Protein G purified in PBS pH 7.4.
• Format: Lyophilized
• Reconstitution: For reconstitution, add 250 µl of sterile water
• Storage Conditions: Lyophilized antibody can be stored at -20°C for up to 3 years. Re-constituted antibody can be stored at 4°C for several days to weeks. Once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.