Anti-E(z) | Histone-lysine N-methyltransferase E(z)

Anti-E(z) | Histone-lysine N-methyltransferase E(z)

• Background: Histone-lysine N-methyltransferase (Ez)is a Polycomb group (PcG) protein, and a catalytic subunit of the Esc/E(z) complex. By methylating Lys-9 and Lys-27 of histone H3, this complex is involved in transcriptional repression of target genes. E(z) is important for the repression during the first six hours of embryogenesis. The Esc/E(z) complex, together with the recruitment of the PRC1 complex, is necessary for the repression of homeotic target genes.Alternative names: Lysine N-methyltransferase 6, Protein enhancer of zeste
• CAS Number: 9007-83-4
• Host: Rabbit
• Reactivity: Drosophila melanogaster
• Immunogen: GST-fusion with amino acids 8-190 of theDrosophila melanogasterE(z) protein, UniProt:P42124
• Clonality: Polyclonal
• Applications: Chromatin Immunoprecipitation (IP) (ChIP)
• Dilution: 3 µg/IP (ChIP)
• Purity: Immunogen affinity purified and depleted of anti-GST antibodies, in PBS pH 7.4.
• Format: Lyophilized
• Reconstitution: For reconstitution add 50 µl of sterile water
• Molecular Weight: 86.9 kDa
• Storage Conditions: Lyophilized antibody can be stored at -20°C for up to 3 years. Re-constituted antibody can be stored at 4°C for several days to weeks. Once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.