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Nelotanserin

CAT: 0804-HY-10559-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-10559-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Nelotanserin is a potent 5-HT2A inverse agonist, a moderately potent 5-HT2C partial inverse agonist and a weak 5-HT2B inverse agonist, with IC50s of 1.7, 79, 791 nM in IP accumulation assays, respectively.
CAS Number
839713-36-9
Product Name Alternative
APD125
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Nelotanserin.html
Purity
99.66
Solubility
DMSO : ≥ 32 mg/mL
Smiles
COC1=C(C2=C(Br)C=NN2C)C=C(NC(NC3=C(F)C=C(F)C=C3)=O)C=C1
Molecular Formula
C18H15BrF2N4O2
Molecular Weight
437.24
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Al-Shamma HA et al. Nelotanserin, a novel selective human 5-hydroxytryptamine2A inverse agonist for the treatment of insomnia. J Pharmacol Exp Ther. 2010 Jan;332 (1) :281-90.|[2]Teegarden BR et al. Discovery of 1-[3- (4-bromo-2-methyl-2h-pyrazol-3-yl) -4-methoxyphenyl]-3- (2,4-difluorophenyl) urea (nelotanserin) and related 5-hydroxytryptamine2A inverse agonists for the treatment of insomnia. J Med Chem. 2010 Mar 11;53 (5) :1923-36.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
5-HT2 Receptor; α-1 microglobulin

Alternative Products

CatalogName
460638-01Nelotanserin
A21506-100Nelotanserin 100mg
A21506-5Nelotanserin 5mg
A21506-1Nelotanserin 1mg
A21506-500Nelotanserin 500mg
A21506-50Nelotanserin 50mg
A21506-25Nelotanserin 25mg
A21506-10Nelotanserin 10mg
A21506-2Nelotanserin 2mg
A21506-10mM-DNelotanserin 10mM * 1mL in DMSO

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