STRA13 Polyclonal Antibody

CAT: 0866-RD85407A-01Size: 60 μLDry Ice: NoHazardous: No
CAT#:0866-RD85407A-01Size:60 μL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks (PubMed:20347428, PubMed:20347429) . In complex with CENPS, CENPT and CENPW (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression. As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure.
Description
This is a STRA13 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
CENPX, CENP-X, D9, FAAP10, MHF2, STRA13
Gene ID
201254
Swiss Prot
A8MT69
Reactivity
Human
Immunogen
Recombinant fusion protein of human STRA13 (NP_659435.2) .
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1 mg/mL
Dilution
WB 1:500-1:2000
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
6 kDa/7 kDa/8 kDa
Observed Molecular Weight
14 kDa
Host or Source
Rabbit
Isotype
IgG

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