STRA13 Polyclonal Antibody

• Background:

  DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks (PubMed:20347428, PubMed:20347429) . In complex with CENPS, CENPT and CENPW (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression. As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure.

• Description:

  This is a STRA13 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms:

  CENPX, CENP-X, D9, FAAP10, MHF2, STRA13

• Gene ID:

  201254

• Swiss Prot:

  A8MT69

• Reactivity:

  Human

• Immunogen:

  Recombinant fusion protein of human STRA13 (NP_659435.2) .

• Conjugation:

  Unconjugated

• Type:

  Polyclonal Antibody

• Applications:

  WB

• Purification Method:

  Affinity purification

• Assay Type:

  Antibody

• Concentration:

  1 mg/mL

• Dilution:

  WB 1:500-1:2000

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3

• Storage Conditions:

  Store at -20°C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  6 kDa/7 kDa/8 kDa

• Observed Molecular Weight:

  14 kDa

• Host or Source:

  Rabbit

• Isotype:

  IgG