STRAP Polyclonal Antibody

CAT: 0866-RD89383A-01Size: 60 μLDry Ice: NoHazardous: No
CAT#:0866-RD89383A-01Size:60 μL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs, the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein.
Description
This is a STRAP Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
STRAP, MAWD, PT-WD, UNRIP, serine-threonine kinase receptor-associated protein
Gene ID
11171
Swiss Prot
Q9Y3F4
Reactivity
Human, Mouse
Immunogen
Recombinant fusion protein of human STRAP
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB, IF, IP
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1mg/mL
Dilution
WB 1:500-1:2000, IF 1:50-1:200, IP 1:50-1:200
Buffer
PBS with 0.02% sodium azide,50% glycerol, pH7.3.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Calculated Molecular Weight
51kDa/55kDa
Observed Molecular Weight
Refer to figures
Host or Source
Rabbit
Isotype
IgG

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