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SIGLEC12 Polyclonal Antibody

CAT: 0866-RD85157A-01Size: 60 μLDry Ice: NoHazardous: No
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CAT#:0866-RD85157A-01Size:60 μL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster with other SIGLEC3-like genes on 19q13.4. Alternative splicing results in multiple transcript variants.
Description
This is a SIGLEC12 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
SIGLEC12, S2V, SIGLECL1, SLG, Siglec-XII
Gene ID
89858
Swiss Prot
Q96PQ1
Reactivity
Mouse
Immunogen
Recombinant fusion protein of human SIGLEC12 (NP_443729.1) .
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1 mg/mL
Dilution
WB 1:500-1:2000
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
51 kDa/64 kDa
Observed Molecular Weight
80 kDa
Host or Source
Rabbit
Isotype
IgG

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