ERBB4 Polyclonal Antibody

• Background:

  This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

• Description:

  This is a ERBB4 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms:

  ALS19, HER4, p180erbB4, ERBB4, HER4/ErbB4

• Gene ID:

  2066

• Swiss Prot:

  Q15303

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein of human ERBB4 (NP_005226.1) .

• Conjugation:

  Unconjugated

• Type:

  Polyclonal Antibody

• Applications:

  IHC

• Purification Method:

  Affinity purification

• Assay Type:

  Antibody

• Concentration:

  1 mg/mL

• Dilution:

  IHC 1:50-1:100

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3

• Storage Conditions:

  Store at -20°C. Avoid freeze / thaw cycles.

• Host or Source:

  Rabbit

• Isotype:

  IgG