ERBB2 Polyclonal Antibody

CAT: 0866-RD70397A-01Size: 60 μLDry Ice: NoHazardous: No
CAT#:0866-RD70397A-01Size:60 μL
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Background
HER2, also known as ErbB2 and Neu, is a 185-kDa transmembrane glycoprotein that is a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. It has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Amplification and/or overexpression of HER2 have been reported in numerous cancers, including breast and ovarian tumors. HER2 is a therapeutic target for the treatment of breast cancer and other carcinomas.
Description
This is a ERBB2 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog, C erb B2/neu protein, CD340, CD340 antigen, Cerb B2/neu protein, CerbB2, Erb b2 receptor tyrosine kinase 2, ERBB2, ERBB2, HER 2, HER 2/NEU, HER2, Herstatin, Human epi
Swiss Prot
P04626, P70424
Reactivity
Human
Immunogen
KLH conjugated Synthetic peptide corresponding to Mouse ErbB2
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1.3 mg/mL
Dilution
WB 1:500-1:2000
Buffer
PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
138 kDa
Observed Molecular Weight
185 kDa
Host or Source
Rabbit
Isotype
IgG

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