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PTPRC Polyclonal Antibody

CAT: 0866-RD82539A-01Size: 60 μLDry Ice: NoHazardous: No
CAT#:0866-RD82539A-01Size:60 μL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.
Description
This is a PTPRC Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
B220, CD45, CD45R, GP180, L-CA, LCA, LY5, T200, PTPRC
Gene ID
5788
Swiss Prot
P08575
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide of human PTPRC (NP_002829.2) .
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB, IHC, IF
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1 mg/mL
Dilution
WB 1:500-1:2000 IHC 1:50-1:200 IF 1:50-1:200
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
130 kDa/147 kDa
Observed Molecular Weight
185 kDa
Host or Source
Rabbit
Isotype
IgG

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