CD209 Polyclonal Antibody

CAT: 0866-RD81865A-01Size: 60 μLDry Ice: NoHazardous: No
CAT#:0866-RD81865A-01Size:60 μL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332; often referred to as L-SIGN) . DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.
Description
This is a CD209 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
CD209, CDSIGN, CLEC4L, DC-SIGN, DC-SIGN1
Gene ID
30835
Swiss Prot
Q9NNX6
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein of human CD209 (NP_066978.1) .
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1 mg/mL
Dilution
WB 1:500-1:2000
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
4 kDa/18 kDa/30-45 kDa
Observed Molecular Weight
46 kDa
Host or Source
Rabbit
Isotype
IgG

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