MDM2 Polyclonal Antibody

• Background:

  This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells.

• Description:

  This is a MDM2 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms:

  MDM2, ACTFS, HDMX, hdm2

• Gene ID:

  4193

• Swiss Prot:

  Q00987

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein of human MDM2 (NP_002383.2) .

• Conjugation:

  Unconjugated

• Type:

  Polyclonal Antibody

• Applications:

  WB

• Purification Method:

  Affinity purification

• Assay Type:

  Antibody

• Concentration:

  1 mg/mL

• Dilution:

  WB 1:500-1:2000

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3

• Storage Conditions:

  Store at -20°C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  11-14 kDa/24-55 kDa

• Observed Molecular Weight:

  55 kDa

• Host or Source:

  Rabbit

• Isotype:

  IgG