ACTN1 Polyclonal Antibody

• Background:

  Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene.

• Description:

  This is a ACTN1 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms:

  ACTN1, BDPLT15

• Gene ID:

  87

• Swiss Prot:

  P12814

• Reactivity:

  Human, Mouse

• Immunogen:

  Recombinant fusion protein of human ACTN1 (NP_001123477.1) .

• Conjugation:

  Unconjugated

• Type:

  Polyclonal Antibody

• Applications:

  WB, IHC

• Purification Method:

  Affinity purification

• Assay Type:

  Antibody

• Concentration:

  1 mg/mL

• Dilution:

  WB 1:500-1:2000 IHC 1:50-1:200

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3

• Storage Conditions:

  Store at -20°C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  102 kDa/103 kDa/105 kDa/107 kDa

• Observed Molecular Weight:

  105 kDa

• Host or Source:

  Rabbit

• Isotype:

  IgG