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SFPQ Polyclonal Antibody

CAT: 0866-RD80169A-01Size: 60 μLDry Ice: NoHazardous: No
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CAT#:0866-RD80169A-01Size:60 μL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45, a phosphorylated form is sequestered by THRAP3 from the pre-mRNA in resting T-cells; T-cell activation and subsequent reduced phosphorylation is proposed to lead to release from THRAP3 allowing binding to pre-mRNA splicing regulatotry elements which represses exon inclusion. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. May be involved in a pre-mRNA coupled splicing and polyadenylation process as component of a snRNP-free complex with SNRPA/U1A.
Description
This is a SFPQ Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
SFPQ, POMP100, PPP1R140, PSF
Gene ID
6421
Swiss Prot
P23246
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein of human SFPQ (NP_005057.1) .
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB, IHC, IF
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1 mg/mL
Dilution
WB 1:500-1:1000 IHC 1:50-1:100 IF 1:50-1:100
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
72 kDa/76 kDa
Observed Molecular Weight
115 kDa
Host or Source
Rabbit
Isotype
IgG

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