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RAF1 Polyclonal Antibody

CAT: 866-RD79984A-01Size: 60 μLDry Ice: NoHazardous: No
60 μLSelected
PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene is the cellular homolog of viral raf gene (v-raf) . The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.
Description
This is a RAF1 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
CMD1NN, CRAF, NS5, Raf-1, c-Raf, RAF1
Gene ID
5894
Swiss Prot
P04049
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein of human RAF1 (NP_002871.1) .
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB, IHC, IF
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1 mg/mL
Dilution
WB 1:500-1:2000 IHC 1:50-1:200 IF 1:50-1:200
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
73 kDa/75 kDa
Observed Molecular Weight
73 kDa
Host or Source
Rabbit
Isotype
IgG

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