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ADO Polyclonal Antibody

CAT: 0866-RD78396A-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0866-RD78396A-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Human thiol dioxygenases include cysteine dioxygenase (CDO, MIM 603943) and cysteamine (2-aminoethanethiol) dioxygenase (ADO, EC 1.13.11.19) . CDO adds 2 oxygen atoms to free cysteine, whereas ADO adds 2 oxygen atoms to free cysteamine to form hypotaurine. Mouse Ado has strong and specific dioxygenase activity in vitro towards cysteamine but not cysteine. Recombinant Ado was shown to bind iron. Overexpression of Ado in HepG2/C3A cells increased the production of hypotaurine from cysteamine. Similar results were found with human ADO. When endogenous expression of ADO was reduced by RNA-mediated interference, hypotaurine production decreased. The demonstration of high levels of ADO in brain challenges the previous assumption that most of the taurine in the brain is a consequence of CDO activity.
Description
This is a ADO Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
2 aminoethanethiol dioxygenase,2-aminoethanethiol dioxygenase, ADO 2 aminoethanethiol (cysteamine) dioxygenase, ADO, AEDO, C10orf22, Chromosome 10 open reasing frame 22, cysteamine (2-aminoethanethiol) dioxygenase (ADO), Cysteamine dioxygenase, DKFZp564C046, FLJ14
Swiss Prot
Q96SZ5
Accession Number
NP_116193
Reactivity
Human, Mouse
Immunogen
Synthetic peptide of human ADO
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB, IHC, ELISA
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
0.3 mg/mL
Dilution
WB 1:1000-1:5000, IHC 1:25-1:100
Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
30 kDa
Host or Source
Rabbit
Isotype
IgG

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