GNAS Polyclonal Antibody

This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses.

This is a GNAS Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

AHO, GSA, GSP, POH, GPSA, NESP, GNAS1, PHP1A, PHP1B, PHP1C, C20orf45

P63092

BC002722

Human, Mouse, Rat

Recombinant protein of human GNAS

Unconjugated

Polyclonal Antibody

WB, IHC, ELISA

Affinity purification

Antibody

0.4 mg/mL

WB 1:200-1:1000, IHC 1:25-1:100

PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Store at -20°C. Avoid freeze / thaw cycles.

46 kDa

Rabbit