HSD11B2 Polyclonal Antibody

• Background:

  There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor.

• Description:

  This is a HSD11B2 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms:

  11 beta HSD2,11 beta hydroxysteroid dehydrogenase type 2,11 DH2,11-beta-HSD2,11-beta-hydroxysteroid dehydrogenase type 2,11-DH2, AME, AME1, Corticosteroid 11 beta dehydrogenase isozyme 2, Corticosteroid 11-beta-dehydrogenase isozyme 2, DHI2, HSD11B2, HSD11K, HSD2

• Swiss Prot:

  P80365

• Accession Number:

  NP_000187

• Reactivity:

  Human

• Immunogen:

  Synthetic peptide of human HSD11B2

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Polyclonal Antibody

• Applications:

  IHC, ELISA

• Purification Method:

  Affinity purification

• Assay Type:

  Antibody

• Concentration:

  0.6 mg/mL

• Dilution:

  IHC 1:50-1:200

• Buffer:

  PBS with 0.05% sodium azide and 50% glycerol, PH7.4

• Storage Conditions:

  Store at -20°C. Avoid freeze / thaw cycles.

• Host or Source:

  Rabbit

• Isotype:

  IgG