DIO2 Polyclonal Antibody
CAT:
866-RD76811A-02
Size:
60 μL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
DIO2 Polyclonal Antibody
- Background: The protein encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease and thyroid adenomas. This protein contains selenocysteine (Sec) residues encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in multiple transcript variants encoding different isoforms.
- Synonyms: 5DII,D2,Deiodinase,iodothyronine,type II,DIO2,DIOII,EC 1.97.1.10,IOD2,ITDI2,SelY,Thyroxine deiodinase,type II,TXDI2,Type 2 DI,Type 2 iodothyronine deiodinase,Type II 5' deiodinase,Type II iodothyronine deiodinase,Type-II 5''-deiodinase
- CAS Number: 9007-83-4
- Swiss Prot: Q92813
- Accession Number: NP_000784
- Host: Rabbit
- Reactivity: Human,Mouse,Rat
- Immunogen: Synthetic peptide of human DIO2
- Clonality: Polyclonal
- Isotype: IgG
- Conjugation: Unconjugated
- Applications: IHC,ELISA
- Purification: Affinity purification
- Concentration: 0.9 mg/mL
- Dilution: IHC 1:25-1:100
- Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4
- Storage Conditions: Store at -20°C. Avoid freeze / thaw cycles.