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DIO2 Polyclonal Antibody

CAT: 0866-RD76811A-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0866-RD76811A-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3) . It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease and thyroid adenomas. This protein contains selenocysteine (Sec) residues encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in multiple transcript variants encoding different isoforms.
Description
This is a DIO2 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
5DII, D2, Deiodinase, iodothyronine, type II, DIO2, DIOII, EC 1.97.1.10, IOD2, ITDI2, SelY, Thyroxine deiodinase, type II, TXDI2, Type 2 DI, Type 2 iodothyronine deiodinase, Type II 5' deiodinase, Type II iodothyronine deiodinase, Type-II 5''-deiodinase
Swiss Prot
Q92813
Accession Number
NP_000784
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide of human DIO2
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
IHC, ELISA
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
0.9 mg/mL
Dilution
IHC 1:25-1:100
Buffer
PBS with 0.05% sodium azide and 50% glycerol, PH7.4
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Host or Source
Rabbit
Isotype
IgG

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