AKT1 Polyclonal Antibody

Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity) . General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI (3) K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I) . Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. Promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase. The activated form can suppress FoxO gene transcription and promote cell cycle progression. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly.

This is a AKT1 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

AKT 1, AKT, AKT1, AKT1, MGC99656, PKB, PKB-ALPHA, PRKBA, Protein Kinase B Alpha, Protein kinase B, Proto-oncogene c-Akt, RAC Alpha, RAC, RAC-alpha serine/threonine-protein kinase, RAC-PK-alpha

P31749

Human, Mouse, Rat

Synthesized peptide derived from human Akt1 around the non-phosphorylation site of Thr450.

Unconjugated

Polyclonal Antibody

WB, IHC-p, ELISA

Affinity purification

Antibody

1 mg/mL

WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:5000

PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4

Store at -20°C. Avoid freeze / thaw cycles.

56 kDa

55 kDa

Rabbit