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NPHS1 Polyclonal Antibody

CAT: 0866-RD70413A-01Size: 60 μLDry Ice: NoHazardous: No
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CAT#:0866-RD70413A-01Size:60 μL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. The gene is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Mutations in this gene result in Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes.In Western blots, nephrin antibodies generated against the two terminal extracellular Ig domains of recombinant human nephrin recognized a 180-kDa protein in lysates of human glomeruli and a 150-kDa protein in transfected COS-7 cell lysates.
Description
This is a NPHS1 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
CNF, Nephrin, Nephrosis 1 congenital Finnish type, Nephrosis 1, congenital, Finnish type (nephrin), NPHN, NPHN, NPHS 1, Nphs1, Renal glomerulus specific cell adhesion receptor, Renal glomerulus-specific cell adhesion receptor
Swiss Prot
Q9QZS7
Reactivity
Mouse
Immunogen
KLH conjugated Synthetic peptide corresponding to Mouse Nephrin
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
IHC
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1.3 mg/mL
Dilution
IHC 1:1000-1:2000
Buffer
PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Host or Source
Rabbit
Isotype
IgG

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