Beta Amyloid Polyclonal Antibody

• Background:

  Aβ derives from APP via proteolytic cleavage by proteases called α-, β- and γ-secretase. The α-secretase cleavage precludes the formation of Aβ, while the β- and γ-cleavages generate APP components with amyloidogenic features. Amyloid beta A4 precursor protein (APP), encoded by APP gene which locate on human chromosome 21q, is a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. APP expressed in all fetal tissues and is pronounced in brain, kidney, heart and spleen, but weak in liver. Defects in APP are the cause of Alzheimer disease type 1 (AD1) .

• Description:

  This is a beta Amyloid Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms:

  A4 amyloid protein, A4, AAA, ABETA, ABPP, AD1, AICD-50, AICD-57, AICD-59, AID (50), AID (57), AID (59), Alzheimer disease amyloid protein, Amyloid beta (A4) precursor protein, Amyloid beta A4 protein, Amyloid beta protein, Amyloid intracellular domain 50, Amyloid intracellul

• Swiss Prot:

  P12023, P08592

• Reactivity:

  Mouse, Rat

• Immunogen:

  KLH conjugated Synthetic peptide corresponding to Mouse APP

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Polyclonal Antibody

• Applications:

  IHC

• Purification Method:

  Affinity purification

• Assay Type:

  Antibody

• Concentration:

  130 μg/mL

• Dilution:

  IHC 1:200-1:800

• Buffer:

  PBS with 0.02% sodium azide, 1% BSA and 50% glycerol, pH7.4

• Storage Conditions:

  Store at -20°C. Avoid freeze / thaw cycles.

• Host or Source:

  Rabbit

• Isotype:

  IgG