BRCA2 Polyclonal Antibody

• Background:

  Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele.

• Description:

  This is a BRCA2 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms:

  BRCA 2, BRCC 2, Breast and ovarian cancer susceptibility gene early onset antibody, BROVCA2, FACD, FAD 1, FANCB, GLM3

• Swiss Prot:

  P51587

• Reactivity:

  Human, Rat

• Immunogen:

  Recombinant Human Breast cancer type 2 susceptibility protein

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Polyclonal Antibody

• Applications:

  WB, IHC, IF

• Purification Method:

  Antigen Affinity Purification

• Assay Type:

  Antibody

• Concentration:

  1 mg/mL

• Dilution:

  WB 1:1000-1:3000 IHC 1:100-1:200 IF 1:100-1:400

• Buffer:

  PBS with 0.05% Proclin300 and 50% glycerol, pH7.4.

• Storage Conditions:

  Store at -20°C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  384 kDa

• Observed Molecular Weight:

  384 kDa

• Host or Source:

  Rabbit

• Isotype:

  IgG