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Danthron

CAT: 0804-HY-B0923-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-B0923-02Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Danthron is a natural product extracted from the traditional Chinese medicine Salvia miltiorrhiza Bunge. Danthron functions in regulating glucose and lipid metabolism by activating AMPK.
CAS Number
117-10-2
Product Name Alternative
Dantron; Chrysazin; 1,8-Dihydroxyanthraquinone
UNSPSC
12352005
Hazard Statement
H315, H319, H335, H351
Target
AMPK; Autophagy; Bacterial; Virus Protease
Type
Natural Products
Related Pathways
Anti-infection; Autophagy; Epigenetics; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Danthron.html
Purity
99.41
Solubility
DMSO : 5 mg/mL (ultrasonic)
Smiles
O=C1C2=C(C=CC=C2O)C(C3=CC=CC(O)=C13)=O
Molecular Formula
C14H8O4
Molecular Weight
240.21
Precautions
H315, H319, H335, H351
References & Citations
[1]Zhou R, et al. Danthron activates AMP-activated protein kinase and regulates lipid and glucose metabolism in vitro. Acta Pharmacol Sin. 2013 Aug;34 (8) :1061-9.|[2]Zhang H, et al. Danthron functions as a retinoic X receptor antagonist by stabilizing tetramers of the receptor. J Biol Chem. 2011 Jan 21;286 (3) :1868-75.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
Launched
Isoform
AMPK

Chemical Information

1,8-Dihydroxyanthraquinone

Dantron (Chrysazin; 1,8-Dihydroxyanthraquinone) can cause cancer according to The World Health Organization's International Agency for Research on Cancer (IARC).

CAS Number117-10-2
PubChem CID2950
IUPAC Name1,8-dihydroxyanthracene-9,10-dione
Molecular FormulaC14H8O4
Molecular Weight240.21
XLogP3.2
Topological Polar Surface Area74.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count0
Heavy Atom Count18
Formal Charge0
Complexity346
SMILES
C1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C=CC=C3O
InChI
InChI=1S/C14H8O4/c15-9-5-1-3-7-11(9)14(18)12-8(13(7)17)4-2-6-10(12)16/h1-6,15-16H
InChIKey
QBPFLULOKWLNNW-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 1,8-Dihydroxyanthraquinone
CAS: 117-10-2
CID: 2950
Formula: C14H8O4
MW: 240.21
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight240.21
XLogP33.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count0
Exact Mass240.04225873
Monoisotopic Mass240.04225873
Topological Polar Surface Area74.6 Ų
Heavy Atom Count18
Formal Charge0
Complexity346
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BUP19608Danthron
AR-A06672-01Danthron-d4 (1,8-Dihydroxyanthraquinone-d4)

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