GTF2H2 Polyclonal Antibody

This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. This gene is within the telomeric copy of the duplication. Deletion of this gene sometimes accompanies deletion of the neighboring SMN1 gene in spinal muscular atrophy (SMA) patients but it is unclear if deletion of this gene contributes to the SMA phenotype. This gene encodes the 44 kDa subunit of RNA polymerase II transcription initiation factor IIH which is involved in basal transcription and nucleotide excision repair. Transcript variants for this gene have been described, but their full length nature has not been determined. A second copy of this gene within the centromeric copy of the duplication has been described in the literature. It is reported to be different by either two or four base pairs; however, no sequence data is currently available for the centromeric copy of the gene.

This is a GTF2H2 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

GTF2H2, BTF2, BTF2P44, T-BTF2P44, TFIIH, p44

2966

Q13888

Mouse, Rat

A synthetic peptide of human GTF2H2 (NP_001506.1) .

Unconjugated

Polyclonal Antibody

IHC

Affinity purification

Antibody

1 mg/mL

IHC 1:50-1:200

PBS with 0.02% sodium azide, 50% glycerol, pH7.3

Store at -20°C. Avoid freeze / thaw cycles.

Rabbit