Products for Research Use Only
RegisterLogin

CDK5R1 Polyclonal Antibody

CAT: 0866-RD266296A-01Size: 60 μLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0866-RD266296A-01Size:60 μL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5) ; the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease.
Description
This is a CDK5R1 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
CDK5R1, CDK5P35, CDK5R, NCK5A, p23, p25, p35, p35nck5a
Gene ID
8851
Swiss Prot
Q15078
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein of human CDK5R1 (NP_003876.1) .
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
IF
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1 mg/mL
Dilution
IF 1:50-1:200
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Host or Source
Rabbit
Isotype
IgG

Related Products

CatalogName
RD266603A-01CDK5RAP1 Polyclonal Antibody
RD267703A-01CDKAL1 Polyclonal Antibody
RD252531A-01CDKAL1 Polyclonal Antibody
RD79983A-01CDK1 Polyclonal Antibody
RD90335A-01CDK1 Polyclonal Antibody
RD89516A-01CDK5 Polyclonal Antibody
RD83467A-01CDK5 Polyclonal Antibody
RD70486A-01CDK1 Polyclonal Antibody
RD70036A-01CDK1 Polyclonal Antibody
RD82632A-01CDK1 Polyclonal Antibody

Alternative Products

CatalogName
MBS8571667-01CDK5R1 Polyclonal Antibody
TA355439Cdk5r1 Rabbit Polyclonal Antibody
BS2065-01CDK5R1 (Q31) polyclonal antibody
TA374564p35 (CDK5R1) Rabbit Polyclonal Antibody
GTR17744427-01CDK5R1/p35 Rabbit Polyclonal Antibody
GTR18398114Cdk5r1 Rabbit Polyclonal Antibody (FITC)
E10G30279CDK5R1 (p35) Rabbit Polyclonal Antibody
TMAB-04170-01Anti-CDK5R1/p35 Polyclonal Antibody
GTR18398112Cdk5r1 Rabbit Polyclonal Antibody (HRP)
GTR18398111Cdk5r1 Rabbit Polyclonal Antibody (Biotin)

Popular Products