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TNFSF10 Polyclonal Antibody

CAT: 0866-RD265857A-01Size: 60 μLDry Ice: NoHazardous: No
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CAT#:0866-RD265857A-01Size:60 μL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Description
This is a TNFSF10 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
TNFSF10, APO2L, Apo-2L, CD253, TL2, TNLG6A, TRAIL
Gene ID
8743
Swiss Prot
P50591
Reactivity
Rat
Immunogen
A synthetic peptide of human TNFSF10 (NP_003801.1) .
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1 mg/mL
Dilution
WB 1:500-1:2000
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
11 kDa/32 kDa
Observed Molecular Weight
20 kDa
Host or Source
Rabbit
Isotype
IgG

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