EDN3 Polyclonal Antibody

• Background :

  The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB) . The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Altered expression of this gene is implicated in tumorigenesis. Alternative splicing results in multiple transcript variants encoding different isoforms.

• Description :

  This is a EDN3 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms :

  EDN3, ET-3, ET3, HSCR4, PPET3, WS4B

• Gene ID :

  1908

• Swiss Prot :

  P14138

• Reactivity :

  Human

• Immunogen :

  Recombinant fusion protein of human EDN3 (NP_996917.1) .

• Conjugation :

  Unconjugated

• Type :

  Polyclonal Antibody

• Applications :

  WB

• Purification Method :

  Affinity purification

• Assay Type :

  Antibody

• Concentration :

  1 mg/mL

• Dilution :

  WB 1:500-1:2000

• Buffer :

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3

• Storage Conditions :

  Store at -20°C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight :

  23 kDa/25 kDa

• Observed Molecular Weight :

  44 kDa

• Host or Source :

  Rabbit

• Isotype :

  IgG