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APAF1 Polyclonal Antibody

CAT: 0866-RD265705A-01Size: 60 μLDry Ice: NoHazardous: No
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CAT#:0866-RD265705A-01Size:60 μL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC) . Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms.
Description
This is a APAF1 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
APAF1, APAF-1, CED4
Gene ID
317
Swiss Prot
O14727
Reactivity
Human
Immunogen
Recombinant fusion protein of human APAF1 (NP_863651.1) .
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
WB
Purification Method
Affinity purification
Assay Type
Antibody
Concentration
1 mg/mL
Dilution
WB 1:500-1:2000
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
37 kDa/133 kDa/135 kDa/137 kDa/140 kDa/141 kDa
Observed Molecular Weight
142 kDa
Host or Source
Rabbit
Isotype
IgG

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