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FKBPL Polyclonal Antibody

CAT: 0866-RD252239A-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0866-RD252239A-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
FKBPL, also named as DIR1, NG7 and WISp39, has similarity to the immunophilin protein family, which plays a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This protein is thought to have a potential role in the induced radioresistance, probably by increasing the rate of DNA repair in cells exposed to X rays. Also it appears to have some involvement in general stress response in the control of the cell cycle. It regulates p21 protein stability by binding to Hsp90 and p21. Breast cancer cells stably overexpressing FKBPL became dependent on estrogen for their growth and were dramatically more sensitive to the antiestrogens tamoxifen and fulvestrant, whereas FKBPL knockdown reverses this phenotype. FKBPL is an estrogen-inducible gene that acts as a cochaperone in ERα/Hsp90 molecular complexes; furthermore, FKBPL levels may be both a prognostic indicator and determinant of response to endocrine therapy.
Description
This is a FKBPL Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
DIR1, FK506 binding protein like, FK506-binding protein-like, Fkbpl, FKBPL, NG7, OTTHUMP00000029170, WAF 1/CIP1 stabilizing protein 39, WAF-1/CIP1 stabilizing protein 39, WISP39
Swiss Prot
Q9UIM3
Accession Number
BC004168
Reactivity
Human, Mouse, Rat
Immunogen
Fusion protein of human FKBPL
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
IHC, ELISA
Purification Method
Antigen affinity purification
Assay Type
Antibody
Concentration
1.3 mg/mL
Dilution
IHC 1:30-1:150, ELISA 1:2000-1:10000
Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Host or Source
Rabbit
Isotype
IgG

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