NIPBL Polyclonal Antibody

NIPBL Polyclonal Antibody

• Background: This gene encodes the homolog of the Drosophila melanogaster Nipped-B gene product and fungal Scc2-type sister chromatid cohesion proteins. The Drosophila protein facilitates enhancer-promoter communication of remote enhancers and plays a role in developmental regulation. It is also homologous to a family of chromosomal adherins with broad roles in sister chromatid cohesion, chromosome condensation, and DNA repair. The human protein has a bipartite nuclear targeting sequence and a putative HEAT repeat. Condensins, cohesins and other complexes with chromosome-related functions also contain HEAT repeats. Mutations in this gene result in Cornelia de Lange syndrome, a disorder characterized by dysmorphic facial features, growth delay, limb reduction defects, and cognitive disability. Two transcript variants encoding different isoforms have been found for this gene.
• Synonyms: CDLS,Colon tumor susceptibility 2,Delangin,DKFZp434L1319,FLJ11203,FLJ12597,FLJ13354,FLJ13648,FLJ44854,IDN 3,IDN 3 protein,IDN 3 protein isoform A,IDN 3 protein isoform B,IDN 3B,IDN3 B,IDN3 protein,IDN3 protein isoform A,IDN3 protein isoform B,IDN3B,Mis 4,Mis4,Nipbl,NIPBL,Nipped B homolog (Drosophila),Nipped B homolog,Nipped B like,Nipped B like protein,Nipped-B-like protein,Scc 2,SCC 2 homolog,Scc2,SCC2 homolog,Sister chromatid cohesion protein Mis4
• CAS Number: 9007-83-4
• Swiss Prot: Q6KC79
• Accession Number: BC033847
• Host: Rabbit
• Reactivity: Human, Mouse
• Immunogen: Fusion protein of human NIPBL
• Clonality: Polyclonal
• Isotype: IgG
• Conjugation: Unconjugated
• Applications: IHC,ELISA
• Purification: Antigen affinity purification
• Concentration: 0.9 mg/mL
• Dilution: IHC 1:50-1:200, ELISA 1:5000-1:10000
• Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
• Storage Conditions: Store at -20°C. Avoid freeze / thaw cycles.