NARF Polyclonal Antibody

• Background:

  Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment. However, another role for prenylation appears to be its importance in protein-protein interactions. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins. Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif. This post-translationally modified cysteine residue is removed from prelamin A when it is endoproteolytically processed into mature lamin A. The protein encoded by this gene binds to the prenylated prelamin A carboxyl-terminal tail domain. It may be a component of a prelamin A endoprotease complex. The encoded protein is located in the nucleus, where it partially colocalizes with the nuclear lamina. It shares limited sequence similarity with iron-only bacterial hydrogenases. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene, including one with a novel exon that is generated by RNA editing.

• Description:

  This is a NARF Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

• Synonyms:

  DKFZp434G0420, FLJ10067, GC17P078009, IOP2, Iron only hydrogenase like protein 2, Nuclear prelamin A recognition factor, Prenyl dependent prelamin A binding protein

• Swiss Prot:

  Q9UHQ1

• Accession Number:

  BC016440

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Fusion protein of human NARF

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Polyclonal Antibody

• Applications:

  IHC, ELISA

• Purification Method:

  Antigen affinity purification

• Assay Type:

  Antibody

• Concentration:

  1.56 mg/mL

• Dilution:

  IHC 1:50-1:300, ELISA 1:5000-1:10000

• Buffer:

  PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

• Storage Conditions:

  Store at -20°C. Avoid freeze / thaw cycles.

• Host or Source:

  Rabbit

• Isotype:

  IgG