NARF Rabbit Polyclonal Antibody

CAT: 1444-APRab14409-01Size: 20 µLDry Ice: NoHazardous: No
CAT#:1444-APRab14409-01Size:20 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Several proteins have been found to be prenylated and methylated at their carboxyl-terminal ends. Prenylation was initially believed to be important only for membrane attachment. However, another role for prenylation appears to be its importance in protein-protein interactions. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins. Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif. This post-translationally modified cysteine residue is removed from prelamin A when it is endoproteolytically processed into mature lamin A. The protein encoded by this gene binds to the prenylated prelamin A carboxyl-terminal tail domain. It may be a component of a prelamin A endoprotease complex. The encoded protein is located in the nucleus, where it partially colocalizes with the nuclear lamina. ItPTM:Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Belongs to the NARF family., subunit:Interacts with LMNA and binds to the farnesylated C-terminal domain., tissue specificity:Ubiquitous. Predominantly expressed in skeletal muscle, heart and brain.
Product Name Alternative
NARF; Nuclear prelamin A recognition factor; Iron-only hydrogenase-like protein 2; IOP2
Gene Name
NARF
Gene ID
26502
Swiss Prot
Q9UHQ1
Host
Rabbit
Reactivity
Human, Rat, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Applications
WB, IHC, ELISA
Purification
Affinity purification
Dilution
WB 1:500-1:2000, IHC 1:50-1:300, ELISA 1:2000-1:20000
Form
Liquid
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Modification
Unmodified
Molecular Weight
51kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.
Isotype
IgG

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