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IRGC Polyclonal Antibody

CAT: 0866-RD218127A-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0866-RD218127A-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Immunity-related GTPases (IRG) (also known as p47 GTPases) are a family of GTPase proteins found in vertebrates, which play critical roles in mediating innate resistance to intracellular pathogens. IRG genes have been found in a number of mammals and lower species including mice, rats, zebrafish and humans. Most of the mouse genes contain interferon-stimulated response elements which mediate transcriptional activation by IFNs. In humans, only two IRG genes have been found: human IRGC encodes a full-length IRG protein that, like the mouse homologue, is constitutively expressed in testis, while human IRGM encodes a considerably truncated protein that is constitutively expressed in cultured cells including some macrophage cell lines. As the two human genes IRGC and IRGM are not subject to IFN control, it has been suggested that the host resistance mechanism supported by IRG proteins in the mouse is lacking in humans.
Description
This is a IRGC Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.
Synonyms
F630044M05Rik, Gm1102, Gm474, IIGP5, IIGP5, Immunity-related GTPase cinema 1, Interferon-inducible GTPase 5, IRGC, IRGC1, RGD1311107
Swiss Prot
Q6NXR0
Accession Number
NP062558
Reactivity
Human, Rat
Immunogen
Synthetic peptide of human IRGC
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal Antibody
Applications
IHC, ELISA
Purification Method
Antigen affinity purification
Assay Type
Antibody
Concentration
0.78 mg/mL
Dilution
IHC 1:30-1:150, ELISA 1:5000-1:10000
Buffer
PBS with 0.05% NaN3 and 40% Glycerol, pH7.4
Storage Conditions
Store at -20°C. Avoid freeze / thaw cycles.
Host or Source
Rabbit
Isotype
IgG

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