Anti-HEMGN Antibody (C-term)

• Background:

  Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB) .

• Description:

  Boster Bio Anti-HEMGN Antibody (C-term) (Catalog # A08422) . Tested in WB application (s) . This antibody reacts with Human.

• Synonyms:

  Hemogen, Erythroid differentiation-associated gene protein, EDAG-1, Hemopoietic gene protein, Negative differentiation regulator protein, HEMGN, EDAG, NDR

• Gene Name:

  HEMGN

• UniProt:

  Q9BXL5

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This HEMGN antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 355-389 amino acids from the C-terminal region of human HEMGN.

• Clonality:

  Polyclonal

• Tissue Specificity:

  Expressed in hematopoietic precursor cells, thyroid and spermatids (at protein level) . Expressed in bone marrow, testis, thymus. Expressed in prostate cancer and ovarian cancer. Also expressed in thymus and thyroid tumors, non-Hodgkin lymphoma, various leukemia cell lines, peripheral blood mononuclear cells (PBMCs) and bone marrow mononuclear cells (BMMCs) of patients with leukemia

• Applications:

  WB

• Field of Research:

  Signal Transduction, Stem Cells

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Dilution:

  WB: 1:2000

• Function:

  Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB) .

• Molecular Weight:

  55341 Da

• Shipping Conditions:

  Available

• Storage Conditions:

  Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

• Fragment:

  Rabbit IgG

• Subcellular Location:

  Nucleus.