Anti-ATAD2 Antibody (N-term)

• Background:

  A large family of ATPases has been described, whose key feature is that they share a conserved region of about 220 amino acids that contains an ATP-binding site. The proteins that belong to this family either contain one or two AAA (ATPases Associated with diverse cellular Activities) domains. AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes. The protein encoded by this gene contains two AAA domains, as well as a bromodomain.

• Description:

  Boster Bio Anti-ATAD2 Antibody (N-term) (Catalog # A03855) . Tested in WB application (s) . This antibody reacts with Human.

• Synonyms:

  ATPase family AAA domain-containing protein 2, AAA nuclear coregulator cancer-associated protein, ANCCA, ATAD2

• Gene Name:

  ATAD2

• UniProt:

  Q6PL18

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This ATAD2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 204-232 amino acids from the N-terminal region of human ATAD2.

• Clonality:

  Polyclonal

• Tissue Specificity:

  Highly expressed in estrogen receptor positive breast tumors and in osteosarcoma tumors.

• Applications:

  WB

• Field of Research:

  Cancer, Metabolism, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Dilution:

  WB: 1:1000

• Function:

  May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.

• Molecular Weight:

  158554 Da

• Shipping Conditions:

  Available

• Storage Conditions:

  Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

• Fragment:

  Rabbit IgG

• Subcellular Location:

  Nucleus