Anti-TLE1 Antibody (N-term)

• Background:

  Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.

• Description:

  Boster Bio Anti-TLE1 Antibody (N-term) (Catalog # A02460-1) . Tested in IF, WB application (s) . This antibody reacts with Human.

• Synonyms:

  Transducin-like enhancer protein 1, E (Sp1) homolog, Enhancer of split groucho-like protein 1, ESG1, TLE1

• Gene Name:

  TLE1

• UniProt:

  Q04724

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This TLE1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 187-221 amino acids from the N-terminal region of human TLE1.

• Clonality:

  Polyclonal

• Tissue Specificity:

  In all tissues examined, mostly in brain, liver and muscle

• Applications:

  IF, WB

• Field of Research:

  Signal Transduction, Stem Cells, Anti-Wnt-Pathway (plus Lgr5) Antibodies

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Function:

  Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. Enhances FOXG1/BF- 1- and HES1-mediated transcriptional repression (By similarity) . The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.

• Molecular Weight:

  83201 Da

• Shipping Conditions:

  Available

• Storage Conditions:

  Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

• Fragment:

  Rabbit IgG

• Subcellular Location:

  Nucleus. Note=Nuclear and chromatin-associated, depending on isoforms and phosphorylation status. Hyperphosphorylation decreases the affinity for nuclear components