Anti-USP2 Antibody

Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells. Regulates the circadian clock by modulating its intrinsic circadian rhythm and its capacity to respond to external cues. Associates with clock proteins and deubiquitinates core clock component PER1 but does not affect its overall stability. Regulates the nucleocytoplasmic shuttling and nuclear retention of PER1 and its repressive role on the clock transcription factors CLOCK and ARNTL/BMAL1 (By similarity) .

Boster Bio Anti-USP2 Antibody (Catalog # M04288) . Tested in WB application (s) . This antibody reacts with Human, African green monkey.

Ubiquitin carboxyl-terminal hydrolase 2, 3.4.19.12, 41 kDa ubiquitin-specific protease, Deubiquitinating enzyme 2, Ubiquitin thioesterase 2, Ubiquitin-specific-processing protease 2, USP2, UBP41

USP2

O75604

Human, African green monkey

This USP2 antibody is generated from a mouse immunized with a recombinant protein between 1-258 amino acids from human USP2.

Clone: 1738CT331.50.87

Expressed in mesangial cells of the kidney and in different types of glomerulonephritides (at protein level)

WB

Cell Biology

This antibody is purified through a protein G column, followed by dialysis against PBS.

WB: 1:2000

1729022019917254198382111729022019838211172902201729022019917254

68072 Da

Available

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

IgG1, k