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Anti-MITF Antibody

CAT: 0519-M00269-3-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0519-M00269-3-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to symmetrical DNA sequences (E-boxes) (5'- CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR) . Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1) . Plays a critical role in the differentiation of various cell types, such as neural crest- derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium.
Description
Boster Bio Anti-MITF Antibody (Catalog # M00269-3) . Tested in WB application (s) . This antibody reacts with Human, Mouse, Rat.
Synonyms
Microphthalmia-associated transcription factor, Class E basic helix-loop-helix protein 32, bHLHe32, MITF, BHLHE32
Gene Name
MITF
UniProt
O75030
Host
Mouse
Reactivity
Human, Mouse, Rat
Immunogen
This MITF antibody is generated from a mouse immunized with a recombinant protein of human MITF.
Clonality
Monoclonal
Clone
Clone: 1607CT834.207.47
Tissue Specificity
Expressed in melanocytes (at protein level) . [Isoform C2]: Expressed in the kidney and retinal pigment epithelium. [Isoform H2]: Expressed in the kidney. [Isoform Mdel]: Expressed in melanocytes.
Applications
WB
Field of Research
Immunology
Purification
This antibody is purified through a protein G column, followed by dialysis against PBS.
Function
10587587226473782788906196477581058758722647378278890619647758366086703660867010587587226473782788906196477581058758722647378278890619647758
Molecular Weight
58795 Da
Shipping Conditions
Available
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Fragment
IgG1, k
Subcellular Location
Nucleus. Cytoplasm. Lysosome membrane Note=When nutrients are present, recruited to the lysosomal membrane via association with GDP-bound RagC/RRAGC (or RagD/RRAGD) : it is then phosphorylated by MTOR (PubMed:23401004, PubMed:36608670) Phosphorylation by MTOR promotes ubiquitination and degradation (PubMed:36608670) . Conversely, inhibition of mTORC1, starvation and lysosomal disruption, promotes dephosphorylation and translocation to the nucleus (PubMed:36608670) . Phosphorylation by MARK3/cTAK1 promotes association with 14-3-3/YWHA adapters and retention in the cytosol (PubMed:16822840) .

UniProtKB · O75030

Microphthalmia-associated transcription factor

MITF_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O75030
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MITF
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B4DJL2, D3K197, E9PFN0, Q14841, Q9P2V0, Q9P2V1, Q9P2V2, Q9P2Y8
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

ActivatorDevelopmental proteinDNA-binding

Disease

AlbinismDeafnessDisease variantMicrophthalmiaOsteopetrosisWaardenburg syndrome

Coding sequence diversity

Alternative splicing

Domain

Coiled coil

Cellular component

CytoplasmLysosomeMembraneNucleus

PTM

Isopeptide bondPhosphoproteinUbl conjugation

Biological process

TranscriptionTranscription regulation

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