Anti-CTNNB1 Antibody (C-term)

• Background:

  1752450318077326180868581895742321262353226473782269993822155184

• Description:

  Boster Bio Anti-CTNNB1 Antibody (C-term) (Catalog # M00004-5) . Tested in WB, IF application (s) . This antibody reacts with Human, Mouse, Rat.

• Synonyms:

  Catenin beta-1, Beta-catenin, CTNNB1, CTNNB

• Gene Name:

  CTNNB1

• UniProt:

  P35222

• Host:

  Mouse

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  This CTNNB1 antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 687-721 amino acids from the C-terminal region of human CTNNB1.

• Clonality:

  Monoclonal

• Clone:

  Clone: 691CT11.2.1

• Tissue Specificity:

  Expressed in several hair follicle cell types: basal and peripheral matrix cells, and cells of the outer and inner root sheaths. Expressed in colon. Present in cortical neurons (at protein level) . Expressed in breast cancer tissues (at protein level) (PubMed:29367600) .

• Applications:

  WB, IF

• Field of Research:

  Cancer, Cardiovascular, Neuroscience, Signal Transduction, Stem Cells, Anti-Wnt-Pathway (plus Lgr5) Antibodies

• Purification:

  This antibody is purified through a protein G column, followed by dialysis against PBS.

• Function:

  17524503180773261808685818957423212623532215518422647378226999381752450318077326180868581895742321262353221551842264737822699938175245031807732618086858189574232126235322155184226473782269993818086858212623531895742322155184

• Molecular Weight:

  85497 Da

• Shipping Conditions:

  Available

• Storage Conditions:

  Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

• Fragment:

  IgG1

• Subcellular Location:

  Cytoplasm. Nucleus. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:B6V8E6}. Cell junction, adherens junction. Cell junction {ECO:0000250|UniProtKB:B6V8E6}. Cell membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Synapse {ECO:0000250|UniProtKB:Q02248} Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q02248}. Note=Colocalized with RAPGEF2 and TJP1 at cell-cell contacts (By similarity) . Cytoplasmic when it is un-stable (highly phosphorylated) or bound to CDH1. Translocates to the nucleus when it is stabilized (low level of phosphorylation) . Interaction with GLIS2 and MUC1 promotes nuclear translocation. Interaction with EMD inhibits nuclear localization. The majority of beta-catenin is localized to the cell membrane. In interphase, colocalizes with CROCC between CEP250 puncta at the proximal end of centrioles, and this localization is dependent on CROCC and CEP250. In mitosis, when NEK2 activity increases, it localizes to centrosomes at spindle poles independent of CROCC. Colocalizes with CDK5 in the cell-cell contacts and plasma membrane of undifferentiated and differentiated neuroblastoma cells. Interaction with FAM53B promotes translocation to the nucleus (PubMed:25183871) . {ECO:0000250|UniProtKB:B6V8E6, ECO:0000269|PubMed:25183871}

• Prediction Reactivity:

  Bovine, Zebrafish