Anti-UIMC1 Antibody (C-term)

• Background:

  Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs) . The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1.

• Description:

  Boster Bio Anti-UIMC1 Antibody (C-term) (Catalog # A06262-2) . Tested in Flow Cytometry, WB application (s) . This antibody reacts with Human.

• Synonyms:

  BRCA1-A complex subunit RAP80, Receptor-associated protein 80, Retinoid X receptor-interacting protein 110, Ubiquitin interaction motif-containing protein 1, UIMC1, RAP80, RXRIP110

• Gene Name:

  UIMC1

• UniProt:

  Q96RL1

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This UIMC1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 567-601 amino acids from the C-terminal region of human UIMC1.

• Clonality:

  Polyclonal

• Tissue Specificity:

  Expressed in testis, ovary, thymus and heart. Expressed in germ cells of the testis.

• Applications:

  Flow Cytometry, WB

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Function:

  2462747219328070

• Molecular Weight:

  79727 Da

• Shipping Conditions:

  Available

• Storage Conditions:

  Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

• Fragment:

  Rabbit IgG

• Subcellular Location:

  Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs)